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The PhD project is an intrinsic part of the major research theme of the laboratory and will be focused on quantitative description of the effects of molecular environment on ligand-receptor bonds. In particular, the effect of contact time between the reactive partners on the probability of bond formation and its resistance will be studied in details. The work will also include technical development to couple the laminar flow chamber with advanced optical microscopy. The design and making of controlled reactive surfaces will be undertaken in collaboration with the Interdisciplinary Center of Nanosciences in Marseille (CiNAM). The candidate should preferentially be a physicist or a biophysicist, who is interested to work at interface of physics and biology, is open to both experimental and modelling approaches and is ready to work in a multidisciplinary team.

Conditions of application: to have obtained a master degree in 2008 and be less than 25 years old.

Exception can be made for outstanding candidates.

Keywords: biophysics of cell adhesion – colloidal probes – molecular recognition – surface microscopies – glycocalyx

Institute:
Adhesion and Inflammation Laboratory
CNRS UMR6212 – INSERM U600
Interface Physics Biology Medicine
Case 937 – 163 Av. de Luminy – 13288 Marseille Cedex 09

Director: Pierre Bongrand (pierre.bongrand@inserm.fr); tel: +33 491828850

Deadline of application:
15th September 2008